Researchers have identified ways in which chemotherapy can damage healthy cells and found that some drugs can add decades of ...

For the first time, scientists have systematically studied the genetic effects of chemotherapy on healthy tissues.

Chlorambucil (N,N-bis(2-chloroethyl)-p-aminophenylbutyric acid) is a bifunctional alkylating drug belonging to the nitrogen mustard group and is widely used as an anticancer agent. As the antitumor ...

The antitumor effects of alkylating agents and cell resistance to them depend on at least three DNA repair systems: a) increase in O6 -methyl-guanine methyl-tranferase (MGMT), also called O6 ...

These cases highlight significant clinical and radiographic response to the combination of DNA damaging agents with platinum and topoisomerase inhibitor-based therapy as well as second line treatment ...

Two agents (compounds 18 and 19) exhibited mean GI 50 values of 96 nM and 182 nM, respectively, in the NCI human tumor cell line panel. Derivatization of the potent DNA cross-linking agent 15 to an N ...

Thus, with this respect, some specific inhibitors of these enzymes such as paramagnetic divalent metal cations (25Mg2+, 43Ca2+, and 67Zn2+) and the ultrashort single-stranded DNA fragments are ...

Article citations More>> Monzaffari, S.M., Beitollani, N., Bousnenri, A. and Samarian, K. (2024) DNA Repair in Malignacies. Amir Kabir University of Technology. has been cited by the following article ...