Early-onset CRC has become increasingly common. ... irritable bowel syndrome, hemorrhoids, or anal fissures over CRC in a young patient. ...

The rise of early-onset colorectal cancer (CRC) may be associated with mutational signatures left from childhood exposure to colibactin-producing bacteria. (Nature) Results of a survey suggested ...

Among members of the Richardson family who carry a mutation in the PSEN1 gene, the average age when symptoms start is 39.

Colorectal cancer (CRC) is the third most common cancer worldwide. More troubling is that what had been a stable incidence is now rising, particularly early-onset CRC – in the birth cohort of the ...

The rise in early-onset cancers like CRC has puzzled many clinicians and cancer researchers. After all, cancer has been seen as a disease of old age, and over the last few decades, significant ...

CRC also exemplifies the challenges of understanding early-onset cancer, as it can be affected by genetic factors, notably Lynch syndrome, as well as lifestyle and changes in the environment.

Early-onset CRC ; Early-onset CRC. Letter March 06, 2025. facebook twitter whatsup linkded email. Early-onset CRC. Colorectal cancer (CRC) is increasingly being diagnosed among younger individuals ...

There were 120 early-onset CRC and 518 late-onset CRC cases who were included in the study, with the mean (SD) age of diagnosis being 43.5 (4.5) years and 63.2 (8.3) years respectively.

Early-onset colorectal cancer (CRC) cases soar worldwide, affecting 27 countries, ... Lynch syndrome is the leading cause of inherited colon cancer due to germ mutations in MMR genes.

Despite this, large-scale genome-wide association studies (GWAS) with gene-environment interaction analyses could better define the contribution of genetic factors to early-onset CRC presentation.