Scientific organizations recently called for a 10-year ban on human germline editing. But will we ever be ready? And how ...

Those include BRCA1 and BRCA2, which occur in about one of every 500 women and confer an increased risk of breast or ovarian cancer, and rarer mutations in a gene called TP53 that causes a disease ...

Pathogenic germline variant discovery in plasma cell disorders: Insights from genetic counseling referrals and testing. Tehilla Brander , Manisha M Balwani , Sundar Jagannath , Samir Parekh , Santiago ...

Key Takeaways. Hereditary breast cancer results from inherited mutations, primarily in BRCA1 and BRCA2, increasing lifetime cancer risk. Additional genes like TP53, PTEN, PALB2, CHEK2, and ATM ...

Unlike so-called somatic gene editing, where one type of cell or tissue (the one where a mutation is wreaking the most havoc and causing disease) is targeted for modification, editing an embryo ...

In addition, we identify a genetic program that balances proliferation and differentiation of the schistosome germline stem cells. Through single-cell transcriptomic and functional comparisons, we ...

In sickle-cell disease scientists must fix the stem cells that go on to make blood. ... Fetal editing might be able to reach those cells more easily. The lure of germline editing, ...

Previous studies led by the researchers have shown that structural variations occurring in specific cell types, like breast cells, can strongly influence gene expression in ways that contribute to ...

Study: Germline-encoded specificities and the predictability of the B cell response.Image Credit: Kateryna Kon/Shutterstock.com Background. Although the evolution of the immunoglobulin genes that ...

In December, the FDA approved the first two cell-based gene therapies for treating sickle cell disease: Casgevy and Lyfgenia. And, like any emerging medical technology, the initial use of the ...

Researchers in Li Zhao‘s lab studied mutations that occur during the production of sperm from germline cells, ... that increases the odds of de novo genetic disorders or certain types of ...