are due to its lower affinity for heparin-binding proteins and endothelial cells, shorter fractionated heparin chain (which allows for better bioavailability), and unsaturable renal elimination.

As a highly potent, natural anticoagulant, heparin is well known as an antithrombotic agent, and it has been shown to inhibit smooth muscle cell proliferation. INTERGARD Heparin grafts incorporate ...

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Aplagon, a clinical stage biopharmaceutical company developing a first-in-class therapeutic for thrombo-inflammatory diseases, known as APAC, a heparin proteoglycan mimetic with antiplatelet and ...

GU ASCO annual meeting featured a session on emerging trends in germ cell tumors and a presentation by Dr. Darren Feldman discussing the landscape of new trials and targets in refractory germ cell ...

Some of Sharfstein’s current work with her lab at UAlbany includes developing heparin, a blood thinner, from hamster ovary cells. Sharfstein is also working with DeepSeq.AI and its CEO Andrew ...

After more than 70 years of effective clinical use, heparin remains the most common anticoagulant in use and one of the most commonly prescribed drugs to hospitalized patients. However ...

By mimicking naturally occurring mast cell-derived heparin proteoglycans, APAC targets arterial injury sites providing long-lasting antithrombotic and anti-inflammatory action in situ. The funding ...