POLG-related diseases disrupt the function of the mitochondria, or "powerhouses" of the cell — starving them of energy.

Genetic testing for hereditary arrhythmia and cardiomyopathy in an area with known founder effects on local genetic variants ...

Prince Frederik, 22, was a founder and the creative director of a foundation that raised awareness of POLG disorder.

Prince Frederik of Luxembourg died from a genetic disease called PolG, but experts hope his passing could bring more ...

Limiting time spent watching television to no more than one hour each day may lower the risk of heart attack, stroke and ...

Researchers at Washington University School of Medicine in St. Louis have uncovered why some patients with a rare genetic ...

A groundbreaking study has uncovered a genetic predisposition driving alarmingly high rates of chronic kidney disease (CKD) ...

Affected populations: POLG-related diseases are a group of rare, incurable conditions caused by inherited gene mutations. These disease-causing mutations are carried by up to 2% of people of ...

Affected populations: PFIC is a group of rare genetic diseases that cause progressive liver failure. The exact prevalence of ...

Acquired DNA mutations found in the SERPINA1 gene can protect liver cells from damage in patients with alpha-1 antitrypsin ...

Johns Hopkins scientists develop mRNA "booster" as potential new way to treat rare genetic diseases marked by too low levels ...

Early research shows a one-time gene therapy has potential for addressing both the liver and lung disease that patients with ...