NEW YORK (Reuters) -Dual risks kept investors on edge ahead of markets reopening late on Sunday, from heightened prospects of a broad Middle East war to U.S.-wide protests against U.S. President Donald Trump that threatened more domestic chaos.

Israeli Defence Minister Israel Katz has said that Iran crossed "red lines" on Friday when its missiles targeted civilian areas in response to Israel's recent wave of attacks. "Iran has crossed red lines by daring to fire missiles at civilian population centres in Israel," he said in a statement.

Israel has escalated its ongoing conflict with Iran, striking the world's largest gas field and other energy infrastructure as part of a two-day assault that had otherwise largely targeted sites and personnel tied to the Islamic Republic's armed forces and nuclear program.

The country’s exports mostly come from Kharg Island in the Persian Gulf. But Israel’s energy facilities are also at risk.

Under the Islamic Republic that took power in 1979, enmity toward Israel has been a core ideological tenet of Iranian foreign policy and a key driver in its regional policy. Over decades, their rivalry played out mainly through indirect actions by Iran and by covert operations from Israel.

U.S. President Donald Trump said on Saturday "this war in Israel-Iran should end," with his comments coming in a social media post on his call with Russian President Vladimir Putin.

Israel’s leader and President Trump appeared to bet they can persevere, but other world leaders warned of unintended outcomes in a volatile region.

Gas prices "will likely start to rise across much of the country later this evening in response to Israel's attacks on Iran, which have caused oil prices to surge," Patrick de Haan, the head of petroleum analysis at GasBuddy, said on Friday in a post on X.

The Lebanese militant group Hezbollah was long considered Iran’s first line of defense in case of a war with Israel

Follow the latest news after Israel launched strikes at Iran, a dramatic escalation in long-running tensions between the two countries.

The decision by the US Agency for Global Media came after the Trump administration pledged to reduce VOA to its “statutory minimum."

Launching weapons from within their territory forces adversaries to look not only outward but also inside for threats, one expert said.