Currently, the standard treatment for CGL involves daily injections of metreleptin, a synthetic version of the hormone leptin, which is naturally produced exclusively by fat tissue. However ...

Clinical study I: Body Weight, Metabolic, and Immune Responses to Metreleptin Versus Placebo Treatment in Obese Hyperleptinemic Subjects with Diabetes No Differential Activation of MAPK Signaling ...

Takeda paid the San Diego–based biotech $75 million upfront for Symlin/metreleptin combination as part of an agreement that could exceed $1 billion if certain development and sales-dependent ...