AHA/ASA Journals7d
Myeloid Fatty Acid Metabolism Activates Neighboring Hematopoietic Stem Cells to Promote Heart Failure With Preserved Ejection Fraction
BACKGROUND: Despite the high morbidity and mortality of heart failure with preserved ejection fraction (HFpEF), treatment ...
Empagliflozin comes off patent, Indian manufacturers set to launch generic versions.
The biggest advantage of the drug going off patent is that the prices will plummet. The patented medicine, sold as Jardiance, ...
Monthly Prescribing Reference17d
GLP-1 Receptor Agonist Use Not Linked to Increased Suicide Risk
The first cohort included 36,082 GLP-1 receptor agonist users and 234,028 DPP-4 inhibitor users, and the second cohort included 32,336 GLP-1 receptor agonist users and 96,212 SGLT-2 inhibitor users.
Frontiers20d
Sodium-glucose co-transporter 2 inhibitors: a pleiotropic drug in humans with promising results in cats
Figure 3. Beneficial effects of SGLT2 inhibitors on the pathophysiology of type 2 diabetes in humans. Many of the benefits that are now recognized were not anticipated when SGLT2i was initially ...
Nature21d
Mechanism of action articles from across Nature Portfolio
Mechanism of action describes the process by which a ... regulating lipid homeostasis. Proton pump inhibitors (PPIs) are prodrugs that are activated by protonation in the highly acidic environment ...
Medical Xpress23d
Five days of ultra-processed food: Study finds that's enough to alter insulin and reward functions in the brain
More information: Stephanie Kullmann et al, A short-term, high-caloric diet has prolonged effects on brain insulin action in men, Nature Metabolism (2025). DOI: 10.1038/s42255-025-01226-9 Julian ...
TCTMD24d
Sotagliflozin Reduces Ischemic Risk in SCORED Analysis
The mechanism of action remains “the million-dollar question,” he ... Santos-Gallego said he wouldn’t necessarily promote using sotagliflozin over other SGLT2 inhibitors in all patients, though he ...
pharmaphorum25d
Merck, Pfizer covering bases with SGLT2 inhibitor latecomer
Merck and Pfizer are hoping to cover all bases if they get their latest SGLT2 inhibitor to market. There is a crowd of already-approved rivals, but the companies are doing their best to ensure ...
SciTech Daily27d
New FDA-Approved Diabetes Drug Slashes Heart Attack and Stroke Risk
Unlike other SGLT2 inhibitors, sotagliflozin more effectively blocks SGLT1, offering a unique mechanism of action. The study, published February 14 in The Lancet Diabetes & Endocrinology, is the first ...
KRON4 News27d
Microbiotica unveils data on the mechanism of action of MB310, a clinical-stage drug candidate in development for the treatment of ulcerative colitis
Data from new preclinical studies presented at the congresses demonstrated that MB310 acts via at least three independent mechanisms of action (MOA) that are central to the pathology of UC ...
clinicaladvisor.com28d
SGLT-2 Inhibitors Reduce Liver Cirrhosis Risk in Type 2 Diabetes
SGLT-2 inhibitors, compared with DPP-4 inhibitors, were associated with a lower risk for liver cirrhosis among patients with type 2 diabetes. Sodium-glucose cotransporter 2 (SGLT-2) inhibitors ...