BACKGROUND: Despite the high morbidity and mortality of heart failure with preserved ejection fraction (HFpEF), treatment ...

The biggest advantage of the drug going off patent is that the prices will plummet. The patented medicine, sold as Jardiance, ...

The first cohort included 36,082 GLP-1 receptor agonist users and 234,028 DPP-4 inhibitor users, and the second cohort included 32,336 GLP-1 receptor agonist users and 96,212 SGLT-2 inhibitor users.

Figure 3. Beneficial effects of SGLT2 inhibitors on the pathophysiology of type 2 diabetes in humans. Many of the benefits that are now recognized were not anticipated when SGLT2i was initially ...

This ischemic benefit of sotagliflozin on both MI and stroke has not been observed in trials of selective SGLT2 inhibitors ... SGLT1 inhibition as a potential mechanism for the ischemic benefit ...

“Half an hour after we presented the ESC guidelines in 2021, we saw the presentation of EMPEROR-Preserved” — the first trial of a sodium-glucose cotransporter 2 (SGLT2) inhibitor ...

More information: Stephanie Kullmann et al, A short-term, high-caloric diet has prolonged effects on brain insulin action in men, Nature Metabolism (2025). DOI: 10.1038/s42255-025-01226-9 Julian ...

Conclusions In this large cohort study, the use of GLP-1 receptor agonists was not associated with an increased risk of suicidality compared with the use of DPP-4 inhibitors or SGLT-2 inhibitors in ...

While in-depth mechanistic studies at the molecular level, such as identifying precise targets or pathways impacted by the LBP strain, are not explicitly required by the FDA,16 they can provide ...

The mechanism of action remains “the million-dollar question,” he ... Santos-Gallego said he wouldn’t necessarily promote using sotagliflozin over other SGLT2 inhibitors in all patients, though he ...