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rmdopen.bmj2d
Efficacy of tofacitinib monotherapy in methotrexate-naive patients with early or established rheumatoid arthritis
Introduction Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Tofacitinib monotherapy was previously shown to inhibit structural damage, reduce clinical ...
rmdopen.bmj2d
Efficacy and safety of non-pharmacological and non-biological pharmacological treatment: a systematic literature review informing the 2016 update of the ASAS/EULAR ...
To assess the efficacy and safety of non-biological therapies in patients with axial spondyloarthritis (axSpA) to inform the update of the Assessment of SpondyloArthritis international Society ...
rmdopen.bmj3d
Dysregulated long non-coding RNA in Sjögren’s disease impacts both interferon and adaptive immune responses
Objective Sjögren’s disease (SjD) is an autoimmune disease characterised by inflammatory destruction of exocrine glands. Patients with autoantibodies to Ro/SSA (SjD Ro+) exhibit more severe disease.
rmdopen.bmj3d
Patient Reported Outcome Measures for Rheumatoid Arthritis Disease Activity: a systematic review following COSMIN guidelines
Background The current standard of care in rheumatoid arthritis (RA) requires regular assessment of disease activity (DA). All standard RA DA measurement instruments require joint counts to be ...
rmdopen.bmj3d
Development and reliability of a novel ultrasonographic joint-specific scoring system for synovitis with reference atlas for patients with juvenile idiopathic arthritis
Objective To develop an ultrasonographic image acquisition protocol and a joint-specific scoring system for synovitis with reference atlas in patients with juvenile idiopathic arthritis (JIA) and to ...
rmdopen.bmj6d
Smoking, alcohol consumption and disease-specific outcomes in rheumatic and musculoskeletal diseases (RMDs): systematic reviews informing the 2021 EULAR recommendations for ...
Background A EULAR taskforce was convened to develop recommendations for lifestyle behaviours in rheumatic and musculoskeletal diseases (RMDs). The aim of this paper was to review the literature on ...
rmdopen.bmj7d
Are cleaning activities a source of exposure to crystalline silica in women with rheumatoid arthritis? A case–control study
Inhalation of crystalline silica (silicon dioxide, SiO 2) is associated with rheumatoid arthritis (RA). Research on the role of SiO 2 in human disease has been traditionally focused on occupational ...
rmdopen.bmj7d
Do you tweet?: trailing the connection between Altmetric and research impact!
Social media has profoundly changed the way we communicate and interact. Social media interaction brings new demands and challenges to our private and professional lives and has led to the development ...
rmdopen.bmj7d
Integration of transcriptome and immunophenotyping data highlights differences in the pathogenetic kinetics of B cells across immune-mediated disease
Objective To elucidate crucial immune cell subsets and associated immunological pathways by stratifying patients with immune-mediated diseases (IMDs) using immunophenotyping and transcriptomic ...
rmdopen.bmj8d
Insights into osteoarthritis development from single-cell RNA sequencing of subchondral bone
The composition, function and OA-associated changes of cells in human tibial subchondral bone. OA, osteoarthritis. By comparing healthy lateral side (Ctrl) and destructed medial side (OA), the authors ...
rmdopen.bmj8d
Association of mitochondrial RNA expression levels in saliva and plasma with interferon signature gene expression and disease activity in patients with Sjögren disease
Objective To unveil the clinical implications of mitochondrial RNAs (mt-RNAs) in Sjögren disease (SjD), this study evaluated mt-RNA expression levels in the plasma and saliva of patients with SS and ...