Creating models for primary tauopathies sounds simple enough. Select a human tau gene variant that causes disease, stick it where the endogenous mouse gene sits in its genome, then wait a few months ...

Now that doctors are prescribing anti-amyloid therapies for Alzheimer’s disease, scientists have begun to focus their energy on the other pathological hallmark of AD, neurofibrillary tangles. While ...

Neurofibrillary tangles mark Alzheimer’s disease and a plethora of primary tauopathies. How best to study them in the lab? Most mouse tauopathy models overexpress the human tau protein and are highly ...

Yanling Wang Rush University Contact Information Yanling Wang Chicago Professional Information Associate Professor Rush University ...

In a milestone for Alzheimer’s disease diagnosis and care, the U.S. Food and Drug Administration on May 16 cleared for marketing the first AD blood test. Fujirebio’s Lumipulse G p-tau217/Aβ42 ...

As biomarker testing becomes more common in Alzheimer’s research, scientists face the tricky question of whether to disclose results. In studies of hypothetical scenarios, including a recent survey ...

What are physicians learning from their early experiences prescribing amyloid immunotherapy? In the May 12 JAMA Neurology, Joy Snider and Suzanne Schindler and colleagues at Washington University, St.

Perhaps our most defining characteristic as a species, the six-layered human cortex, hosts billions of neural connections that bestow Homo sapiens with higher-order thinking. But how does this ...

Delivery Courier? Microglia Drop Neprilysin Off Near Plaques in Brain Add To My AlzForum 5 Comments 25 Apr 2025 The cells reduced the amount of amyloid and improved downstream aspects of Alzheimer’s ...