In the first episode of The Deep End Podcast, we meet Jon Nelson, who shares why he volunteered to get brain implants for his relentless depression.

The following is a summary of “Esketamine Treatment for Depression in Adults: A PRISMA Systematic Review and Meta-Analysis,” published in the January 2025 issue of Psychiatry by Fountoulakis et al.

People with treatment-resistant depression can now take Spravato's ketamine-derived nasal spray as a standalone treatment.

“The depression was just a constant,” says Winograd, 54, who lives in Portland, Oregon. Around that time, a doctor friend told him about ketamine for treatment-resistant depression. It wasn ...

Researchers at CU Anschutz are studying the effect of psychedelic mushrooms on patients with treatment-resistant depression.

GH Research's inhaled psychedelic therapy GH001 has shown promise in a mid-stage trial in treatment-resistant depression (TRD ...

The small, Ireland-based company GH Research said its inhaled version of mebufotenin — a molecular cousin to psilocybin — was ...

Depression is a pervasive mental health condition affecting millions of people worldwide. It can manifest in various ways, from persistent sadness to a lack of energy or interest in daily activities.

In a Phase IIb trial, GH001 elicited significant drops in treatment-resistant depression. The news comes less than two weeks ...

an inhalable treatment for treatment-resistant depression (TRD), demonstrating a significant placebo-adjusted reduction in depression scores as measured by the MADRS scale on Day 8. The trial ...

Gregory Mattingly, MD, president, Midwest Research Group, founding partner, St. Charles Psychiatric Associates, discusses the ...

Ketamine therapy has become known for its effects at combating depression and other mood disorders. There’s a growing body of ...