In the midst of its longest losing streak in eight years, Virginia will once again look to get back on track in another ACC rematch, as the Cavaliers travel to take on Louisville on Saturday afternoon just two weeks after these two teams first played back in Charlottesville.

Top-ranked teams in the Big 12 meet. We continue our College Basketball odds series with a Iowa State-West Virginia prediction and pick.

Iowa State has lost its last eight games at West Virginia and is 2-9 there all-time. The Cyclones have outscored Big 12 foes by an average of 14 points per game. WVU is coached by Darian DeVries, who left Drake in March. He was 150-55 over six seasons at Drake, and led the Bulldogs to three NCAA tournament appearances.