Speedball, powerball, or over and under[1] is the polydrug mixture of a stimulant with a depressant, usually an opioid. The most well-known mixture used for recreational drug use is …

Aug 27, 2025 · A speedball is a dangerous mix of a stimulant (most often cocaine) and a depressant (most often heroin or another opioid). This combination is especially risky because …

Feb 10, 2021 · A speedball is a combination of heroin and cocaine taken intravenously. It can cause harmful effects and requires treatment to manage addiction.

Mar 14, 2025 · A speedball is a combination of a stimulant (usually cocaine or methamphetamine) and a CNS depressant (typically an opioid), used simultaneously to produce an intense and …

Jul 31, 2025 · A speedball is a dangerous combination of a stimulant drug, such as cocaine, and a depressant drug, most commonly heroin. The two drugs have opposite effects on the body, …

Sep 19, 2024 · When a speedball is injected, the body is forced to process the two types of drugs simultaneously. Taking heroin and cocaine together causes a “push-pull” reaction in the body. …

Jan 29, 2025 · The term “speedball” refers to a combination of opioids and stimulants used for recreational purposes. Usually, a speedball is a combination of cocaine (a stimulant) and …