He is also known for his roles in various films and shows such as Anchorman: The Legend of Ron Burgundy (2004), Tenacious D in the Pick of Destiny (2006), and Easy A (2010), alongside voice roles in The Looney Tunes Show (2011), The Mitchells vs. the Machines (2021), The Lego Ninjago Movie (2017), and Final Space (2018), among others.

Portlandia: Created by Fred Armisen, Carrie Brownstein, Jonathan Krisel. With Fred Armisen, Carrie Brownstein, Kyle MacLachlan, Sam Adams. A sketch-comedy series that parodies life in Portland, Oregon.

Fred Armisen, Tim Heidecker and John C. Reilly star in this new comedy series as three astronauts trying to qualify for their first lunar mission. They encounter obstacles along the way including loneliness, self-doubt and incompetence.

Forever: Created by Matt Hubbard, Alan Yang. With Maya Rudolph, Fred Armisen, Catherine Keener, Noah Robbins. June and Oscar live a comfortable but very predictable suburban wedded life when suddenly they find themselves in a completely otherworldly situation, raising questions about love and marriage in the afterlife.

With Fred Armisen, Tom Kenny, Olan Rogers, Tika Sumpter. An astronaut named Gary and his planet-destroying sidekick called Mooncake embark on serialized journeys through space in order to unlock the mystery of where the universe actually ends and if it actually does exist.

Toast of Tinseltown: With Matt Berry, Doon Mackichan, Fred Armisen, Tim Downie. Steven Toast is determined to win the recognition he mistakenly believes he deserves.

Alongside Fred Armisen, she is the writer, actress and co-developer of the sketch comedy show Portlandia (2011) on IFC TV.

The Looney Tunes Show: With Jeff Bergman, Bob Bergen, Fred Armisen, Kristen Wiig. An updated iteration of the classic Looney Tunes characters focusing on their satirical misadventures living in suburbia.

Documentary Now!: Created by Fred Armisen, Bill Hader, Seth Meyers, Rhys Thomas. With Helen Mirren, Fred Armisen, Bill Hader, Deb Hiett. "Documentary Now!" parodies the current obsession with documentaries. Season one features six different stories and stylistic approaches paying tribute to the doc format.

He is also known for his roles in various films and shows such as Anchorman: The Legend of Ron Burgundy (2004), Tenacious D in the Pick of Destiny (2006), and Easy A (2010), alongside voice roles in The Looney Tunes Show (2011), The Mitchells vs. the Machines (2021), The Lego Ninjago Movie (2017), and Final Space (2018), among others.